RESprotect combines the strengths of classical pharmacology with the mechanistic approach of genomics. The pharmacological approach is highly relevant from a biological perspective because it monitors the pharmacological response of the intact system - either cell or animal - whilst it provides little information regarding the mechanistic level.

A complementing strategy for drug discovery integrating the molecular mechanisms into a final read out is the approach of genomics, which reduces the assay system to its individual molecular components. Genomics and functional genomics have provided a continuous supply of new targets. However, the understanding of definitive implications of genes and proteins involved in the underlying pathophysiology of disease remains a challenge.

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